Associate Principal Scientist, Regenerative Immunology

Job Description

ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs.

With ICR, you'll get to:

• Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
• Contribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideas
• Design and optimize directed-differentiation protocols to generate functional, TECs from human iPSCs
• Build, characterize and validate 3D thymic organoids capable of supporting de novo T-cell development
• Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm

Please apply if you have:

• A PhD or MD/PhD
• At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology
• Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineering

Ideally, you'll also have:

• Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitution
• Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell culture
• Experience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitution
• Even if you don't meet all of these criteria, please apply anyway

And you'll need:

• An easygoing, friendly personality
• The ability to work in the United States without sponsorship

If you don't combine your cover letter with your CV or resume when you apply through LinkedIn, after you apply please send your cover letter only to: with "Cover Your name " as the Subject line.

Position title and compensation are commensurate with experience.

The compensation ranges listed below are starting ranges.

Starting base pay range: $160,000/yr - $215,000/yr

Starting bonus range: $10,000/yr - $20,000/yr